Gliomas are the most common primary brain neoplasms. Unfortunately, grading of gliomas, which is of significant clinical importance, is challenging due to sampling errors With standard MRI sequence a reliable targeting of biopsy is often impossible. More advanced MRI techniques are urgently needed which could provide new means of characterizing and visualizing brain tissue.

Non-invasive quantitative characterization is potentially a promising approach. Imaging of healthy volunteers is a pre-requisition to develop optimal imaging protocols and analyses methods for patients with brain tumors. Understanding of age related changes is crucial for quantitative analyses. The aim of our study is to develop novel imaging protocols suitable for the brain MRI and to detect age related changes by the means of rotating frame and diffusion weighted imaging.