Multiple sclerosis continues to be a major health problem by being the most common disabling neurological disorder of young adults, excluding post traumatic injury. In the current study, 40 patients with relapsing remitting multiple sclerosis and 40 patients with secondary progressive multiple sclerosis will undergo 2 repeated magnetic resonance imaging examinations performed one year apart each other. The aim of the study is to develop novel imaging protocols suitable for patients with multiple sclerosis using advanced magnetic resonance techniques such as rotating frame relaxation imaging. In addition, we aim to study the correlation between advanced MRI parameters and clinical disease progression.